NMN Repair Damaged Cell DNA
--- UBETTER ® Extends Telomere Length and Reverses Aging Clock
DNA damage occurs from both exogenous sources — like the excessive sun on our skin, the polluted air we inhale, or pesticide-laden food we consume — as well as endogenous sources, such as the accumulation of free radical compounds that cause oxidative stress in the body.
When this damage is left unchecked, aging progresses more rapidly as cellular senescence, telomere shortening, and oxidative stress occur. Senescent cells are ones that have stopped dividing and become dysfunctional, causing inflammation to nearby cells, shortening lifespan, and increasing the risk of neurodegenerative and metabolic diseases.
Telomere length has a similar association with disease and longevity. Telomeres are the protective end caps to our chromosomes; shortened telomeres are linked to shortened lifespans.
When NAD+ levels are elevated, the bond between PARP1 and DBC1 is disrupted, as DBC1 also has an affinity to bind to NAD+. Therefore, NAD+ binds to DBC1, leaving PARP1 free. Essentially, the more NAD+ that you have, the better that PARP1 is able to function. This leads to improved DNA repair and fewer damaging compounds that contribute to aging.
In a typical aging progression, NAD+ levels decline and more DBC1 binds to PARP1, preventing proper DNA repair. However, this process can be ameliorated by boosting NAD+ through supplemental NMN.
A study published in January 2020 in Nature came up with similar results from cell culture experiments. The researchers used a cell line that expressed XRCC1, which is another protein that is involved in DNA repair. When DNA damage occurs, PARP1 increases the activity of XRCC1.
After inducing damage to the cells via laser micro-irradiation, the NAD+ precursors NMN and NR (nicotinamide riboside) were introduced. They found that the presence of NAD+ led to an upregulation of PARP1 and XRCC1 to repair the damaged DNA.
Although these studies have produced encouraging results, the research thus far has only been done with cell cultures and animals. Therefore, we won’t know for sure if NMN supplementation will also be able to repair damaged DNA in humans until clinical trials are performed.
Reference:
1, Extracellular NAD enhances PARP-dependent DNA repair capacity independently of CD73 activity+
Anna Wilk, Faisal Hayat, Richard Cunningham, Jianfeng Li, Silvia Garavaglia, Leila Zamani, Davide M. Ferraris, Peter Sykora, Joel Andrews, Jennifer Clark, Amanda Davis, Laurent Chaloin, Menico Rizzi, Marie Migaud & Robert W. Sobol Scientific Reports.
What is NAD+?
NAD+ (nicotinamide adenine dinucleotide, referred to as coenzyme appears in many metabolic reactions of cells, and plays an irreplaceable role in the oxidation of ethanal, glycogenolysis, fat metabolism, ATP cycle and respiratory chain.
NAD+ decreases with age. At the age of 50, the NAD+ content is only half of that of young people.
However NAD+ is not absorbed well by the digestive system, nor directly taken up by cells, making its oral supplementation impracticable.
Dietary supplemeritation with NMN can increase the NAD+ levels in cells. Especially in the middle-aged and beyond, it can reactivate cell function, reverse cell cycle, activate longevity gene, extend the length of telomeres, and play the role of anti-aging and prolonging life.
Increasing the level of NAD+ in the body can prevent or reduce senile diseases, such as Alzheimers, memory loss, coronary heart disease, high blood pressure. diabetes, obesity, etc.
What is NAD+?
NAD+ (nicotinamide adenine dinucleotide, referred to as coenzyme appears in many metabolic reactions of cells, and plays an irreplaceable role in the oxidation of ethanal, glycogenolysis, fat metabolism, ATP cycle and respiratory chain.
NAD+ decreases with age. At the age of 50, the NAD+ content is only half of that of young people.
However NAD+ is not absorbed well by the digestive system, nor directly taken up by cells, making its oral supplementation impracticable.
Dietary supplemeritation with NMN can increase the NAD+ levels in cells. Especially in the middle-aged and beyond, it can reactivate cell function, reverse cell cycle, activate longevity gene, extend the length of telomeres, and play the role of anti-aging and prolonging life.
Increasing the level of NAD+ in the body can prevent or reduce senile diseases, such as Alzheimers, memory loss, coronary heart disease, high blood pressure. diabetes, obesity, etc.
New Scientific Research Discovers Human Longevity Supplement —–NMN
Professor David Sinclair of Harvard University’s Genetics and Anti-aging Research Center discovered the mystery of human longevity in 2014 that is, supplementing NMN, a direct precursor of an essential
coenzyme NAD +, can reverse aging and prolong life.
The paper was first published in the top international medical journal European Journal of Molecular Biology (EMBO), and related research results were published in Cell Nature and Science respectively. In 2019, Professor David Sinclair published the New York Times bestseller “Lifespare: Why We Age and Why We Don’t Have To”, and was selected by Times as one of the 100 most influential people in the world, acclaiming him as a famous geneticist who realizes age reversal.
Rapidly Boost NAD+ Levels
The NAD+ levels in the human body can be increased through exercise and diet, but the increase is very low. NMN as a direct precursor of NAD can be supplemented separately and quickly converted into NAD+ in the cells to participate in the whole process of life.
Increasing the NAD + level in the body can enhance the length of telomeres, reverse cell degeneration, repair DNA damage, enhance mitochondrial function, promote the rejuvenation of nerve cells, and effectively improve the health of various organs in the body to effectively achieve reversing aging and healthy longevity.
Rapidly Boost NAD+ Levels
The NAD+ levels in the human body can be increased through exercise and diet, but the increase is very low. NMN as a direct precursor of NAD can be supplemented separately and quickly converted into NAD+ in the cells to participate in the whole process of life.
Increasing the NAD + level in the body can enhance the length of telomeres, reverse cell degeneration, repair DNA damage, enhance mitochondrial function, promote the rejuvenation of nerve cells, and effectively improve the health of various organs in the body to effectively achieve reversing aging and healthy longevity.
