NMN Helps Protect the liver From Alcohol and Reverses Liver Damage

Alcohol itself is not terrible, the acetaldehyde it produces during metabolism is the real culprit. There are three main steps in the metabolism of alcohol:

Alcohol (ethanol) is converted into acetaldehyde under the action of alcohol dehydrogenase (ADH) and NAD+;
Acetaldehyde is converted to acetic acid under the action of aldehyde dehydrogenase 2 (ALDH2) and NAD+;
Acetic acid enters the tricarboxylic acid cycle and is converted into carbon dioxide and water.

Ethanol can make us drunk, but it is not toxic. Acetic acid is simply vinegar, not to mention carbon dioxide and water.

However, acetaldehyde can not only cause DNA damage mutations, but also is a clear carcinogen, and is also inseparable from brain aging, immune aging, bone fractures, and changes in folic acid metabolism (affecting the next generation).

The main place of metabolism of alcohol is the liver, so when drinking alcohol, the liver bears the brunt and suffers the most harm. The liver damage caused by long-term drinking is initially manifested as fatty liver, which can develop into alcoholic hepatitis, liver fibrosis, cirrhosis, and liver cancer; severe alcoholism may also lead to liver failure.

People with normal ALDH2 gene can decompose acetaldehyde in time; when ALDH2 is defective, acetaldehyde can only accumulate in the liver and be slowly oxidized and metabolized by the oxidase P450 in the liver, causing discomforts such as facial flushing, rapid heartbeat, dizziness, nausea, and vomiting, as well as damages to internal organs. Unfortunately, about 30%-50% of Chinese people belong to the ALDH2 gene abnormal group, which means that drinking is more deadly to us.

According to the related chemical reactions of alcohol metabolism, the metabolism of ethanol and acetaldehyde both involve the participation of a key coenzyme NAD+ in the human body. In many studies, taking NMN can quickly increase the NAD+ content in the liver, accelerate the metabolism of alcohol, and thus rapid relief of the hangover effect.

What is NAD+?

NAD+ (nicotinamide adenine dinucleotide, referred to as coenzyme appears in many metabolic reactions of cells, and plays an irreplaceable role in the oxidation of ethanal, glycogenolysis, fat metabolism, ATP cycle and respiratory chain.

NAD+ decreases with age. At the age of 50, the NAD+ content is only half of that of young people.

However NAD+ is not absorbed well by the digestive system, nor directly taken up by cells, making its oral supplementation impracticable.

Dietary supplemeritation with NMN can increase the NAD+ levels in cells. Especially in the middle-aged and beyond, it can reactivate cell function, reverse cell cycle, activate longevity gene, extend the length of telomeres, and play the role of anti-aging and prolonging life.

Increasing the level of NAD+ in the body can prevent or reduce senile diseases, such as Alzheimers, memory loss, coronary heart disease, high blood pressure. diabetes, obesity, etc.

New Scientific Research Discovers Human Longevity Supplement —–NMN

Professor David Sinclair of Harvard University’s Genetics and Anti-aging Research Center discovered the mystery of human longevity in 2014 that is, supplementing NMN, a direct precursor of an essential
coenzyme NAD +, can reverse aging and prolong life.

The paper was first published in the top international medical journal European Journal of Molecular Biology (EMBO), and related research results were published in Cell Nature and Science respectively. In 2019, Professor David Sinclair published the New York Times bestseller “Lifespare: Why We Age and Why We Don’t Have To”, and was selected by Times as one of the 100 most influential people in the world, acclaiming him as a famous geneticist who realizes age reversal.

Rapidly Boost NAD+ Levels

The NAD+ levels in the human body can be increased through exercise and diet, but the increase is very low. NMN as a direct precursor of NAD can be supplemented separately and quickly converted into NAD+ in the cells to participate in the whole process of life.

Increasing the NAD + level in the body can enhance the length of telomeres, reverse cell degeneration, repair DNA damage, enhance mitochondrial function, promote the rejuvenation of nerve cells, and effectively improve the health of various organs in the body to effectively achieve reversing aging and healthy longevity.